#Failure to thrive meaning in adults plus

#Failure to thrive meaning in adults plus

Given the challenges of applying adult-defined PEW criteria to the pediatric population, the authors of a recent study entitled “Protein energy wasting in children with chronic kidney disease” have sought to develop a scoring system and three alterative definitions for this condition using a combination of biochemical markers, clinical measurements, and subjective reporting in children in the CKiD cohort: (1) minimal PEW definition (≥2 adult-defined PEW criteria) (2) standard PEW definition (≥3 adult-defined PEW criteria) (3) modified PEW definition (≥3 adult-defined PEW criteria, plus short stature or poor growth). Emerging data suggest that PEW may also commonly afflict children with CKD and have a negative impact on growth and development (“uremic failure to thrive”), yet it remains comparatively understudied and less well characterized in these patients. In adults with CKD, PEW has typically been defined on the basis of (1) deranged biochemical parameters, (2) reduced body mass, (3) reduced muscle mass, and (4) decreased dietary protein intake. Protein-energy wasting (PEW), a condition of decreased body protein and fat mass, is highly prevalent in patients with chronic kidney disease (CKD) and a potent predictor of mortality in this population.